Effect of glucose or fat challenge on aspirin resistance in diabetes

Hussein N. Yassine; Grace Davis-Gorman; Craig S. Stump; Stephen S. Thomson; Justin Peterson; Paul F. McDonagh

doi:10.1155/2010/820876

Effect of glucose or fat challenge on aspirin resistance in diabetes

Hussein N. Yassine, Grace Davis-Gorman, Craig S. Stump, Stephen S. Thomson, Justin Peterson, Paul F. McDonagh

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Aspirin has lower antiplatelet activity in diabetic patients. Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n = 49) or a 4-hour fat challenge (n = 11). All subjects were currently taking aspirin (81 or 325mg). After fat ingestion, urine thromboxane increased in all subjects (Mean ± SE before: after) (1209 ± 336: 1552 ± 371, P =.01), while we noted a trend increase in VerifyNow measures (408 ± 8: 431 ± 18, P =.1). The response to glucose ingestion was variable. Diabetic subjects with cardiac disease and dyslipidemia increased thromboxane (1693 ± 364: 2799 ± 513, P <.05) and VerifyNow (457.6 ± 22.3: 527.1 ± 25.8, P <.05) measures after glucose. We conclude that saturated fat ingestion increases in vivo thromboxane production despite aspirin therapy.

Original language	English (US)
Article number	820876
Journal	International Journal of Endocrinology
Volume	2010
DOIs	https://doi.org/10.1155/2010/820876
State	Published - 2010

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems

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title = "Effect of glucose or fat challenge on aspirin resistance in diabetes",

abstract = "Aspirin has lower antiplatelet activity in diabetic patients. Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n = 49) or a 4-hour fat challenge (n = 11). All subjects were currently taking aspirin (81 or 325mg). After fat ingestion, urine thromboxane increased in all subjects (Mean ± SE before: after) (1209 ± 336: 1552 ± 371, P =.01), while we noted a trend increase in VerifyNow measures (408 ± 8: 431 ± 18, P =.1). The response to glucose ingestion was variable. Diabetic subjects with cardiac disease and dyslipidemia increased thromboxane (1693 ± 364: 2799 ± 513, P <.05) and VerifyNow (457.6 ± 22.3: 527.1 ± 25.8, P <.05) measures after glucose. We conclude that saturated fat ingestion increases in vivo thromboxane production despite aspirin therapy.",

author = "Yassine, {Hussein N.} and Grace Davis-Gorman and Stump, {Craig S.} and Thomson, {Stephen S.} and Justin Peterson and McDonagh, {Paul F.}",

year = "2010",

doi = "10.1155/2010/820876",

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AU - Yassine, Hussein N.

AU - Davis-Gorman, Grace

AU - Stump, Craig S.

AU - Thomson, Stephen S.

AU - Peterson, Justin

AU - McDonagh, Paul F.

PY - 2010

Y1 - 2010

N2 - Aspirin has lower antiplatelet activity in diabetic patients. Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n = 49) or a 4-hour fat challenge (n = 11). All subjects were currently taking aspirin (81 or 325mg). After fat ingestion, urine thromboxane increased in all subjects (Mean ± SE before: after) (1209 ± 336: 1552 ± 371, P =.01), while we noted a trend increase in VerifyNow measures (408 ± 8: 431 ± 18, P =.1). The response to glucose ingestion was variable. Diabetic subjects with cardiac disease and dyslipidemia increased thromboxane (1693 ± 364: 2799 ± 513, P <.05) and VerifyNow (457.6 ± 22.3: 527.1 ± 25.8, P <.05) measures after glucose. We conclude that saturated fat ingestion increases in vivo thromboxane production despite aspirin therapy.

AB - Aspirin has lower antiplatelet activity in diabetic patients. Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n = 49) or a 4-hour fat challenge (n = 11). All subjects were currently taking aspirin (81 or 325mg). After fat ingestion, urine thromboxane increased in all subjects (Mean ± SE before: after) (1209 ± 336: 1552 ± 371, P =.01), while we noted a trend increase in VerifyNow measures (408 ± 8: 431 ± 18, P =.1). The response to glucose ingestion was variable. Diabetic subjects with cardiac disease and dyslipidemia increased thromboxane (1693 ± 364: 2799 ± 513, P <.05) and VerifyNow (457.6 ± 22.3: 527.1 ± 25.8, P <.05) measures after glucose. We conclude that saturated fat ingestion increases in vivo thromboxane production despite aspirin therapy.

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Effect of glucose or fat challenge on aspirin resistance in diabetes

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ASJC Scopus subject areas

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