Effect of gastric acidity on enoxacin absorption

M. E. Lebsack; David Nix; Bruce Ryerson; Roger D. Toothaker; Linda Welage; Allyn M. Norman; Jerome J. Schentag; Allen J. Sedman

doi:10.1038/clpt.1992.138

Effect of gastric acidity on enoxacin absorption

M. E. Lebsack, David Nix, Bruce Ryerson, Roger D. Toothaker, Linda Welage, Allyn M. Norman, Jerome J. Schentag, Allen J. Sedman

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of gastric acidity on the oral absorption of the quinolone antibiotic enoxacin was evaluated in 12 healthy volunteers. In a randomized, crossover design, single 400 mg oral enoxacin doses were administered on four occasions: alone, after 50 mg intravenous ranitidine, after 2 µg/kg subcutaneous pentagastrin, and after combined ranitidine and pentagastrin treatment. Gastric pH was monitored by radiotelemetry capsule for 4 hours after enoxacin administration. Ranitidine pretreatment reduced enoxacin oral bioavailability by an average of 26%. This effect was abolished when pentagastrin was used to maintain low gastric pH. Thus the ranitidine‐induced decrease in enoxacin oral bioavailability probably results from a decrease in gastric acidity rather than from an interaction with ranitidine itself. Clinical Pharmacology and Therapeutics (1992) 52, 252–256; doi:

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	Clinical Pharmacology & Therapeutics
Volume	52
Issue number	3
DOIs	https://doi.org/10.1038/clpt.1992.138
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1992.138

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AU - Ryerson, Bruce

AU - Toothaker, Roger D.

AU - Welage, Linda

AU - Norman, Allyn M.

AU - Schentag, Jerome J.

AU - Sedman, Allen J.

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Effect of gastric acidity on enoxacin absorption

Abstract

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