Abstract
The emergence of stem cell-based therapies has engendered a new area in ischemic cardiovascular disease. Mesenchymal stem cells (MSCs), also referred to as multipotent stem cells, have emerged as a promising cell source for regenerative medicine. Immune/inflammatory suppression and the paracrine mechanism of MSCs play a critical role in MSC-mediated therapeutic effects in tissue regeneration. Angiogenesis, the process by which new blood vessels are formed from pre-existing vessels, is a critical phenomenon that is activated during various stages of mammalian growth, development, and tissue repair. Here we discuss the role of MSCs in angiogenesis and its underlying mechanism, current knowledge on the transfer, spread, and modulation of angiogenic signals via exosomes, and a new perspective on the emerging role of exosomally circulated proteins and microRNAs on regulation of angiogenesis at the molecular level.
| Original language | English (US) |
|---|---|
| Title of host publication | Mesenchymal Stem Cell Derived Exosomes |
| Subtitle of host publication | The Potential for Translational Nanomedicine |
| Publisher | Elsevier Inc. |
| Pages | 1-29 |
| Number of pages | 29 |
| ISBN (Electronic) | 9780128004975 |
| ISBN (Print) | 9780128001646 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
Keywords
- Angiogenesis
- Exosome
- Mesenchymal stem cells
- Paracrine
- Tissue regeneration
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
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