Effect of Estrogen on Tumor-associated Immunity in Patients with Adenocarcinoma of the Prostate

Richard J. Ablin, Rashid A. Bhatti, Patrick D. Guinan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Tumor-associated antigen-induced leukocyte adherence inhibition has been used as an in vitro criterion for evaluating the effect of estrogen on cell-mediated antitumor-associated immunity in patients with adenocarcinoma of the prostate. Significant (p < 0.05) suppression from the reactivity obtained with untreated patients leukocytes to allogeneic extracts of malignant prostatic tissue ranging from 19 to 80% was observed in all patients following preincubation of their leukocytes with diethylstilbesterol diphosphate. The observed suppression of tumor-associated immunity in the presence of exogenous estrogen provides further evidence to earlier studies that demonstrated estrogenic suppression of nonspecific cellular responsiveness as evaluated by phytohemagglutinin-induced lymphocytic blastogenesis of normal and prostatic cancer patients lymphocytes and for the initially suggested concern over the efficacy of estrogenic therapy and its adverse effect on host cell-mediated immunological responsiveness.

Original languageEnglish (US)
Pages (from-to)3702-3706
Number of pages5
JournalCancer Research
StatePublished - Nov 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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