Effect of diabetes, insulin, and glucose load on lipid peroxidation in the rat

Michael P. Habib, Frank D. Dickerson, Arshag D. Mooradian

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations

    Abstract

    Lipid peroxidative activity in rats made diabetic with streptozocin and rats made acutely hyperglycemic by intraperitoneal dextrose administration was determined by measurement of exhaled ethane during exposure in vivo to ethane-free air (EFA). Diabetic rats demonstrated increased ethane in the expired breath while breathing EFA (5.82 ± 0.56 pmol / min /100 g) compared with control rats (4.02 ± 0.23 pmol/ min/ 100 g). Insulin treatment of diabetic rats attenuated the ethane produced (4.88 ± 0.23 pmol/ min /100 g). Acute hyperglycemia increased exhaled ethane to levels higher than those seen in diabetic rats (9.87 ± 0.98 pmol/ min/ 100 g). Saline injected intraperitoneally to control rats produced ethane levels similar to those of untreated nondiabetic controls (4.11 ± 0.52 pmol/ min / 100 g). Chronic uncontrolled hyperglycemia and acute hyperglycemia are associated with increased in vivo ethane production.

    Original languageEnglish (US)
    Pages (from-to)1442-1445
    Number of pages4
    JournalMetabolism
    Volume43
    Issue number11
    DOIs
    StatePublished - Nov 1994

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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