Abstract
The effect of the vasoactive perivascular neuropeptides calcitonin gene-related peptide on proliferation of cultured human aortic smooth muscle cells (SMC) was investigated. CGPR was shown to induce a concentration-dependent inhibition in DNA synthesis as compared to control cultures with a maximal effect of 47.44% at 10 nmol/L. It was also shown that CGRP inhibited the concentration of cytoplasmic free calcium. The study suggests that CGRP may act as a local inhibitor for the proliferation of SMC. The mechanism of the action is associated with the inhibition of cytoplasmic free calcium.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 324-325 |
| Number of pages | 2 |
| Journal | Acta Academiae Medicinae Hubei |
| Volume | 19 |
| Issue number | 4 |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- Cells, cultured
- CGRP
- Muscle, smooth, vascular
- Thymidine
ASJC Scopus subject areas
- General Medicine
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