Effect of Brij-78 on systemic delivery of insulin from an ocular device

Yung Chi Lee, Pahala Simamora, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13 eye device formulations were evaluated. The efficacy of insulin ocular delivery was quantitated by monitoring the changes in its pharmacological response (i.e., blood glucose lowering). The in vivo results from devices containing 0.5 or 1.0 mg of insulin with 20 μg of p.- 2. ether (Brij-78) give a substantial improvement in insulin activity and a significant prolongation in its duration compared with the eyedrops. In addition, the mean blood glucose concentration returns to nearly normal levels within 60 rain after the removal of the device. Overall, the application of the Gelfoam device makes it feasible to obtain a prolonged systemic delivery of insulin within the desired therapeutic levels without the risk of hypoglycemia.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalJournal of pharmaceutical sciences
Issue number4
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Pharmaceutical Science


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