Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild Norway rats

N. K. Popova; E. M. Nikulina; S. N. Shigantsov; I. F. Plyusnina; T. G. Amstislavskaya

doi:10.1007/BF02447135

Effect of antagonists and agonists of 5-HT₁ and 5-HT₂ serotonin receptors on the predator aggressiveness of wild Norway rats

N. K. Popova, E. M. Nikulina, S. N. Shigantsov, I. F. Plyusnina, T. G. Amstislavskaya

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of agonists of serotonin receptors on predator aggressiveness (the "mouse killing" test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine x HCl (TFMPP) considerably reduces aggressiveness. The serotonin precursor 5-hydroxyptryptophan also lowers it, while the antagonist of 5-HT_2A receptors ketanserin abolishes the inhibitory effect of 5-hydroxytryptophan. Presumably, the inhibitory effects of serotonin on predator aggressiveness are realized via the 5-HT_2A and 5-HT_2C brain serotonin receptors.

Original language	English (US)
Pages (from-to)	621-623
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	121
Issue number	6
DOIs	https://doi.org/10.1007/BF02447135
State	Published - Jun 1996

Keywords

Predator aggressiveness
Types of serotonin receptors

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/BF02447135

Cite this

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title = "Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild Norway rats",

abstract = "The effect of agonists of serotonin receptors on predator aggressiveness (the {"}mouse killing{"} test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine x HCl (TFMPP) considerably reduces aggressiveness. The serotonin precursor 5-hydroxyptryptophan also lowers it, while the antagonist of 5-HT2A receptors ketanserin abolishes the inhibitory effect of 5-hydroxytryptophan. Presumably, the inhibitory effects of serotonin on predator aggressiveness are realized via the 5-HT2A and 5-HT2C brain serotonin receptors.",

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AU - Popova, N. K.

AU - Nikulina, E. M.

AU - Shigantsov, S. N.

AU - Plyusnina, I. F.

AU - Amstislavskaya, T. G.

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