Efeitos da lovastatina na hipercolesterolemia primária.

Translated title of the contribution: Effects of lovastatin in primary hypercholesterolemia

E. R. Nakandakare, R. C. Garcia, J. M. Carré, C. V. Zerbinatti, H. C. Oliveira, E. C. Quintão

Research output: Contribution to journalArticlepeer-review


Lovastatin, a potent inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase, was investigated in a placebo-controlled trial of 26 primary hypercholesterolemic subjects. Drug dosage varied from 20 to 40 mg/d in a single dose on a 12 weeks treatment period. Average plasma cholesterol reduction levels were 17 and 31%, and LDL-cholesterol 24 and 41% on 20 and 40 mg/d respectively. High-density lipoprotein and triglycerides levels did not change significantly. Similar mean decreases in total plasma cholesterol and LDL-cholesterol levels were observed in hypercholesterolemics irrespectively of being of familial origin or not. No serious clinical and laboratory abnormalities were observed. In this study, lovastatin was a well tolerated and effective agent for the treatment of non familial and heterozygous familial hypercholesterolemia.

Translated title of the contributionEffects of lovastatin in primary hypercholesterolemia
Original languagePortuguese
Pages (from-to)291-295
Number of pages5
JournalArquivos brasileiros de cardiologia
Issue number5
StatePublished - May 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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