Abstract
Lovastatin, a potent inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase, was investigated in a placebo-controlled trial of 26 primary hypercholesterolemic subjects. Drug dosage varied from 20 to 40 mg/d in a single dose on a 12 weeks treatment period. Average plasma cholesterol reduction levels were 17 and 31%, and LDL-cholesterol 24 and 41% on 20 and 40 mg/d respectively. High-density lipoprotein and triglycerides levels did not change significantly. Similar mean decreases in total plasma cholesterol and LDL-cholesterol levels were observed in hypercholesterolemics irrespectively of being of familial origin or not. No serious clinical and laboratory abnormalities were observed. In this study, lovastatin was a well tolerated and effective agent for the treatment of non familial and heterozygous familial hypercholesterolemia.
Translated title of the contribution | Effects of lovastatin in primary hypercholesterolemia |
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Original language | Portuguese |
Pages (from-to) | 291-295 |
Number of pages | 5 |
Journal | Arquivos brasileiros de cardiologia |
Volume | 52 |
Issue number | 5 |
State | Published - May 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine