Early-Onset Colorectal Cancer: A Call for Greater Rigor in Epidemiologic Studies

Christine Louise S. Molmenti, Elizabeth T. Jacobs, Samir Gupta, Cynthia A. Thomson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The rates of early-onset colorectal cancer (EO-CRC) have been rising by 0.5% to 2.4% annually for three decades, accounting for an estimated 12% of all colorectal cancer diagnosed in the United States in 2020. Enhancing the rigor and comprehensiveness of the epidemiology in terms of the exposures and prognostic biomarkers is essential if we are to modify risk factors and underlying mechanisms, ultimately arresting this unduly trend. This commentary serves to describe the disease trend, postulate underlying risk factors and mechanisms driving disease incidence, and proposes a call to action for cancer epidemiologists to promote increased and timely opportunities to intervene on this trend.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Issue number3
StatePublished - Mar 2022

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


Dive into the research topics of 'Early-Onset Colorectal Cancer: A Call for Greater Rigor in Epidemiologic Studies'. Together they form a unique fingerprint.

Cite this