Early life growth trajectories in cystic fibrosis are associated with pulmonary function at age 6 years

Don B. Sanders, Aliza Fink, Nicole Mayer-Hamblett, Michael S. Schechter, Gregory S. Sawicki, Margaret Rosenfeld, Patrick A. Flume, Wayne J. Morgan

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Objective To determine whether severity of lung disease at age 6 years is associated with changes in nutritional status before age 6 within individual children with cystic fibrosis (CF). Study design Children with CF born between 1994 and 2005 and followed in the CF Foundation Patient Registry from age ≤2 through 7 years were assessed according to changes in annualized weight-for-length (WFL) percentiles between ages 0 and 2 years and body mass index (BMI) percentiles between ages 2 and 6 years. The association between growth trajectories before age 6 and forced expiratory volume in 1 second (FEV1)% predicted at age 6-7 years was evaluated using multivariable linear regression. Results A total of 6805 subjects met inclusion criteria. Children with annualized WFL-BMI always >50th percentile (N = 1323 [19%]) had the highest adjusted mean (95% CI) FEV1 at 6-7 years (101.8 [100.1, 103.5]). FEV1 at 6-7 years for children whose WFL-BMI increased >10 percentile points by age 6 years was 98.3 (96.6, 100.0). This was statistically significantly higher than FEV1 for children whose WFL-BMI was stable (94.4 [92.6, 96.2]) or decreased >10 percentile points (92.9 [91.1, 94.8]). Among children whose WFL-BMI increased >10 percentile points, achieving and maintaining WFL-BMI >50th percentile at younger ages was associated with significantly higher FEV1 at 6-7 years. Conclusions Within-patient changes in nutritional status in the first 6 years of life are significantly associated with FEV1 at age 6-7 years. The establishment of a clear relationship between early childhood growth measurements and later lung function suggests that early nutritional interventions may impact on eventual lung health.

Original languageEnglish (US)
Pages (from-to)1081-1088.e1
JournalJournal of Pediatrics
Issue number5
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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