Abstract
The process of heart induction appears to be highly conserved among vertebrates. The endoderm is important for heart induction in vertebrates. The details of the mechanism remain poorly understood. The localized inhibition of canonical Wnt signaling, which is regulated by endogenous Wnt antagonists, is required for heart induction. The size of the developing heart is regulated by inhibitory signals. The bone morphogenetic protein (BMP), Wnt, fibroblast growth factor (FGF) and Notch signaling pathways are important during early heart development. Different transcription factor profiles, in different regions of the original heart field, direct differentiation of the individual subdomains of the developing heart. Using a defined set of transcription factors, it is now possible to reprogram non-cardiac cells to the myocardial lineage.
Original language | English (US) |
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Title of host publication | Principles of Developmental Genetics |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 407-420 |
Number of pages | 14 |
ISBN (Print) | 9780124059450 |
DOIs | |
State | Published - 2015 |
Keywords
- Bone morphogenetic protein (BMP)
- Differentiation
- Fibroblast growth factor (FGF)
- Heart development
- Heart induction
- Notch
- Signaling pathway
- Transcription factor
- Wnt
- Wnt signaling
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology