Early handling increases hippocampal long-term potentiation in young rats

D. A. Wilson; J. Willner; E. M. Kurz; L. Nadel

doi:10.1016/0166-4328(86)90240-8

Early handling increases hippocampal long-term potentiation in young rats

D. A. Wilson, J. Willner, E. M. Kurz, L. Nadel

Psychology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The hippocampal formation undergoes major anatomical and physiological changes postnatally, and thus might be expected to be particularly sensitive to early handling effects. Long-term potentiation (LTP) in the hippocampal formation, a form of brain plasticity thought to be important in learning and memory, was examined in young rats following early handling or control treatments. The amplitude of LTP was reliably greater in rats receiving the early handling regime. Possible mechanisms and consequences of enhanced LTP were discussed.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Behavioural Brain Research
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/0166-4328(86)90240-8
State	Published - Sep 1986

Keywords

behavioral development
handling effect
hippocampal development
long-term potentiation

ASJC Scopus subject areas

Behavioral Neuroscience

Access to Document

10.1016/0166-4328(86)90240-8

Cite this

@article{f4b10591267a469aadd843329ebdc41b,

title = "Early handling increases hippocampal long-term potentiation in young rats",

abstract = "The hippocampal formation undergoes major anatomical and physiological changes postnatally, and thus might be expected to be particularly sensitive to early handling effects. Long-term potentiation (LTP) in the hippocampal formation, a form of brain plasticity thought to be important in learning and memory, was examined in young rats following early handling or control treatments. The amplitude of LTP was reliably greater in rats receiving the early handling regime. Possible mechanisms and consequences of enhanced LTP were discussed.",

keywords = "behavioral development, handling effect, hippocampal development, long-term potentiation",

author = "Wilson, {D. A.} and J. Willner and Kurz, {E. M.} and L. Nadel",

note = "Funding Information: This research was supported in part by grants from the March of Dimes Birth Defects Foundation (12-143) to L.N. and from NINCDS to L.N. (NS 17712) and M. Leon (NS 21484). We are grateful to D. Sengelaub for his comments on an earlier version of the paper, and for preparing the figure.",

year = "1986",

month = sep,

doi = "10.1016/0166-4328(86)90240-8",

language = "English (US)",

volume = "21",

pages = "223--227",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Early handling increases hippocampal long-term potentiation in young rats

AU - Wilson, D. A.

AU - Willner, J.

AU - Kurz, E. M.

AU - Nadel, L.

N1 - Funding Information: This research was supported in part by grants from the March of Dimes Birth Defects Foundation (12-143) to L.N. and from NINCDS to L.N. (NS 17712) and M. Leon (NS 21484). We are grateful to D. Sengelaub for his comments on an earlier version of the paper, and for preparing the figure.

PY - 1986/9

Y1 - 1986/9

N2 - The hippocampal formation undergoes major anatomical and physiological changes postnatally, and thus might be expected to be particularly sensitive to early handling effects. Long-term potentiation (LTP) in the hippocampal formation, a form of brain plasticity thought to be important in learning and memory, was examined in young rats following early handling or control treatments. The amplitude of LTP was reliably greater in rats receiving the early handling regime. Possible mechanisms and consequences of enhanced LTP were discussed.

AB - The hippocampal formation undergoes major anatomical and physiological changes postnatally, and thus might be expected to be particularly sensitive to early handling effects. Long-term potentiation (LTP) in the hippocampal formation, a form of brain plasticity thought to be important in learning and memory, was examined in young rats following early handling or control treatments. The amplitude of LTP was reliably greater in rats receiving the early handling regime. Possible mechanisms and consequences of enhanced LTP were discussed.

KW - behavioral development

KW - handling effect

KW - hippocampal development

KW - long-term potentiation

UR - http://www.scopus.com/inward/record.url?scp=0022517680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022517680&partnerID=8YFLogxK

U2 - 10.1016/0166-4328(86)90240-8

DO - 10.1016/0166-4328(86)90240-8

M3 - Article

C2 - 3021181

AN - SCOPUS:0022517680

SN - 0166-4328

VL - 21

SP - 223

EP - 227

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 3

ER -

Early handling increases hippocampal long-term potentiation in young rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this