Early Goal Directed Therapy for Sepsis During Pregnancy

Debra A. Guinn, David E. Abel, Mark W. Tomlinson

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Sepsis is a leading cause of death in pregnancy and results in significant perinatal mortality. These deaths occur despite the younger age of pregnant patients, the low rate of comorbid conditions and the potential for effective interventions that should result in rapid resolution of illness. To date, no "evidence-based" recommendations are specific to the pregnant patient who is critically ill or septic. Optimal care for the septic patient requires a multidisciplinary team with expertise in obstetrics, maternal-fetal medicine, critical care, infectious disease, anesthesia, and pharmacy. Coordination of care and good communication amongst team members is essential. Incorporation of early goal directed therapy for suspected sepsis into obstetric practice is needed to optimize maternal and neonatal outcomes.

Original languageEnglish (US)
Pages (from-to)459-479
Number of pages21
JournalObstetrics and Gynecology Clinics of North America
Issue number3
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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