Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection

Mark R. Wallace; Ronald B. Moss; H. James Beecham; Christopher J. Grace; Evan M. Hersh; Eskild Peterson; Robert Murphy; David H. Shepp; Frederick P. Siegal; John L. Turner; Sharon Safrin; Dennis J. Carlo; Alexandra M. Levine

doi:10.1097/00042560-199608010-00005

Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection

Mark R. Wallace, Ronald B. Moss, H. James Beecham, Christopher J. Grace, Evan M. Hersh, Eskild Peterson, Robert Murphy, David H. Shepp, Frederick P. Siegal, John L. Turner, Sharon Safrin, Dennis J. Carlo, Alexandra M. Levine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In a clinical trial involving asymptomatic, HIV-seropositive subjects treated with either the HIV-1 immunogen (an inactivated, gp120-depleted HIV- 1 virus in incomplete Freund's adjuvant) or an adjuvant control, we examined the relationship between changes in the percentage of CD4 cells over time and early clinical markers of HIV disease progression. Subjects who had an early clinical event were more likely to have a greater decline in the percentage of CD4 cells than those subjects who did not have a clinical event (p = 0.054). The greatest decline in CD4 percentage occurred within 10 weeks prior to a clinical event (mean 11% decrease from baseline). Subjects from the quartile with the greatest decline in CD4 percentage had a fivefold greater risk of having a clinical event than subjects from the quartile with the second largest decline (p = 0.045). These results demonstrate a relationship between changes in the percentage of CD4 cells and early clinical events. Further validation of this association may be useful in clinical monitoring and in evaluating therapies to treat HIV infection.

Original language	English (US)
Pages (from-to)	358-362
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1097/00042560-199608010-00005
State	Published - 1996
Externally published	Yes

Keywords

CD4 percent
Early HIV clinical events
Surrogate markers

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Virology

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10.1097/00042560-199608010-00005

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Wallace, M. R., Moss, R. B., Beecham, H. J., Grace, C. J., Hersh, E. M., Peterson, E., Murphy, R., Shepp, D. H., Siegal, F. P., Turner, J. L., Safrin, S., Carlo, D. J., & Levine, A. M. (1996). Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 12(4), 358-362. https://doi.org/10.1097/00042560-199608010-00005

Wallace, MR, Moss, RB, Beecham, HJ, Grace, CJ, Hersh, EM, Peterson, E, Murphy, R, Shepp, DH, Siegal, FP, Turner, JL, Safrin, S, Carlo, DJ & Levine, AM 1996, 'Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 12, no. 4, pp. 358-362. https://doi.org/10.1097/00042560-199608010-00005

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abstract = "In a clinical trial involving asymptomatic, HIV-seropositive subjects treated with either the HIV-1 immunogen (an inactivated, gp120-depleted HIV- 1 virus in incomplete Freund's adjuvant) or an adjuvant control, we examined the relationship between changes in the percentage of CD4 cells over time and early clinical markers of HIV disease progression. Subjects who had an early clinical event were more likely to have a greater decline in the percentage of CD4 cells than those subjects who did not have a clinical event (p = 0.054). The greatest decline in CD4 percentage occurred within 10 weeks prior to a clinical event (mean 11% decrease from baseline). Subjects from the quartile with the greatest decline in CD4 percentage had a fivefold greater risk of having a clinical event than subjects from the quartile with the second largest decline (p = 0.045). These results demonstrate a relationship between changes in the percentage of CD4 cells and early clinical events. Further validation of this association may be useful in clinical monitoring and in evaluating therapies to treat HIV infection.",

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year = "1996",

doi = "10.1097/00042560-199608010-00005",

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AU - Murphy, Robert

AU - Shepp, David H.

AU - Siegal, Frederick P.

AU - Turner, John L.

AU - Safrin, Sharon

AU - Carlo, Dennis J.

AU - Levine, Alexandra M.

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AB - In a clinical trial involving asymptomatic, HIV-seropositive subjects treated with either the HIV-1 immunogen (an inactivated, gp120-depleted HIV- 1 virus in incomplete Freund's adjuvant) or an adjuvant control, we examined the relationship between changes in the percentage of CD4 cells over time and early clinical markers of HIV disease progression. Subjects who had an early clinical event were more likely to have a greater decline in the percentage of CD4 cells than those subjects who did not have a clinical event (p = 0.054). The greatest decline in CD4 percentage occurred within 10 weeks prior to a clinical event (mean 11% decrease from baseline). Subjects from the quartile with the greatest decline in CD4 percentage had a fivefold greater risk of having a clinical event than subjects from the quartile with the second largest decline (p = 0.045). These results demonstrate a relationship between changes in the percentage of CD4 cells and early clinical events. Further validation of this association may be useful in clinical monitoring and in evaluating therapies to treat HIV infection.

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Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection

Abstract

Keywords

ASJC Scopus subject areas

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