TY - JOUR
T1 - Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging
AU - Sonar, Sandip Ashok
AU - Uhrlaub, Jennifer L.
AU - Coplen, Christopher P.
AU - Sempowski, Gregory D.
AU - Dudakov, Jarrod A.
AU - van den Brink, Marcel R.M.
AU - LaFleur, Bonnie J.
AU - Jergović, Mladen
AU - Nikolich-Žugich, Janko
PY - 2022/4/26
Y1 - 2022/4/26
N2 - SignificanceOlder adults are more vulnerable to infection and less capable of vigorously responding to vaccination. The contribution of peripheral T cell maintenance defects to these processes is incompletely understood. Here, we provide evidence that lymph nodes (LNs), which are critical for naive T (TN) cell maintenance and initiation of new immune responses, age asynchronously. Skin-draining LNs undergo early (6 to 9 mo) and deeper LN and spleen late-life (18 mo) atrophy, characterized by reduced ability to maintain TN cells, structural and numerical loss of LN stromal cell microenvironments, and reduced immunity to cutaneous vaccination. These results highlight the critical role of age-related LN atrophy in functional immunity and immune homeostasis.
AB - SignificanceOlder adults are more vulnerable to infection and less capable of vigorously responding to vaccination. The contribution of peripheral T cell maintenance defects to these processes is incompletely understood. Here, we provide evidence that lymph nodes (LNs), which are critical for naive T (TN) cell maintenance and initiation of new immune responses, age asynchronously. Skin-draining LNs undergo early (6 to 9 mo) and deeper LN and spleen late-life (18 mo) atrophy, characterized by reduced ability to maintain TN cells, structural and numerical loss of LN stromal cell microenvironments, and reduced immunity to cutaneous vaccination. These results highlight the critical role of age-related LN atrophy in functional immunity and immune homeostasis.
KW - T cells
KW - aging
KW - homeostasis
KW - secondary lymphoid organs
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U2 - 10.1073/pnas.2121028119
DO - 10.1073/pnas.2121028119
M3 - Article
C2 - 35439062
AN - SCOPUS:85128792529
VL - 119
SP - e2121028119
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 17
ER -