Dye leaching from a doped sol-gel is eliminated by conjugation to a dendrimer

Muditha D. Senarath-Yapa, S. Scott Saavedra

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The extent of leaching of dye molecules following encapsulation into sol-gel glasses was investigated. Covalent attachment of erythrosin isothiocyanate (EITC) to a polyamidoamine generation 4 (PAMAM) dendrimer, having a molecular weight of 14,215 Da, eliminated all detectable leaching from hydrated monoliths prepared from tetramethylorthosilicate (TMOS). In contrast, a prior study showed that significant leaching takes place when the dye is conjugated to 70 kDa dextran. To eliminate dye leaching via attachment to a macromolecular carrier, an inherently globular macromolecule having an organized secondary structure is therefore required.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalAnalytica Chimica Acta
Issue number1
StatePublished - Mar 22 2001


  • Dendrimer
  • Dye entrapment
  • Dye leaching
  • Optical sensor
  • Sol-gel

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy


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