Dye affinity adsorbent replacement optimization

Armando Tejeda, Juán A. Noriega, Jaime Ortega, Roberto Guzmán

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A method to determine the optimal replacement time for dye affinity adsorbents used in protein purification processes that are subjected to severe regeneration conditions has been developed. To demonstrate the utility of the method, an experimental fixedbed decay model was employed to determine the optimum number of cycles for the adsorbent replacement. This number is a function of the column regeneration frequency and of the capital and operation costs. The implications of the results on the design and operation of dye-ligand chromatographic processes are discussed.

Original languageEnglish (US)
Pages (from-to)493-495
Number of pages3
JournalBiotechnology Progress
Issue number3
StatePublished - May 1998

ASJC Scopus subject areas

  • Biotechnology


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