TY - JOUR
T1 - Dual-task performance is associated with brain MRI Morphometry in individuals with mild cognitive impairment
AU - Grijalva, Carissa
AU - Toosizadeh, Nima
AU - Sindorf, Jacob
AU - Chou, Ying hui
AU - Laksari, Kaveh
N1 - Funding Information:
This work was supported by an award from the National Institute of Aging (NIA) (award number: 1 R21 AG055852‐01) and the NIH T32 Graduate Training Program entitled Biomedical Imaging and Spectroscopy. The findings of this manuscript are those of the authors and do not necessarily represent the official views of NIA. The authors declare that they have no competing interests. We thank an MRI Research Specialist Scott Squire. We also thank Coco Tirambulo for her contribution to MRI data collection.
Funding Information:
This work was supported by an award from the National Institute of Aging (NIA) (award number: 1 R21 AG055852-01) and the NIH T32 Graduate Training Program entitled Biomedical Imaging and Spectroscopy. The findings of this manuscript are those of the authors and do not necessarily represent the official views of NIA. The authors declare that they have no competing interests. We thank an MRI Research Specialist Scott Squire. We also thank Coco Tirambulo for her contribution to MRI data collection.
Publisher Copyright:
© 2021 American Society of Neuroimaging
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Background and Purpose: Cognitive impairment is a critical health problem in the elderly population. Research has shown that patients with mild cognitive impairment (MCI) may develop dementia in later years. Therefore, early identification of MCI could allow for interventions to help delay the progression of this devastating disease. Our objective in this study was to detect the early presence of MCI in elderly patients via neuroimaging and dual-task performance. Methods: Brain MRI scans from 21 older adult volunteers, including cognitively healthy adults (HA, n = 9, age = 68-79 years) and mild cognitively impaired (MCI, n = 12, age = 66-92 years) were analyzed using automatic segmentation techniques. Regional volume, surface area, and thickness measures were correlated with simultaneous performance of motor and cognitive tasks (dual-task) within a novel upper-extremity function (UEF) test, using multivariate analysis of variance models. Results: We found significant associations of dual-task performance with volume of five cortical brain regions (P ≤.048) and thickness of 13 regions (P ≤.043) within the frontal, temporal, and parietal lobes. There was a significant interaction effect of cognitive group on dual-task score for the inferior temporal gyrus volume (P ≤.034), and the inferior parietal lobule, inferior temporal gyrus, and middle temporal gyrus average thickness (P ≤.037). Conclusions: This study highlighted the potential of dual-tasking and MRI morphometric changes as a simple and accurate tool for early detection of cognitive impairment among community-dwelling older adults. The strong interaction effects of cognitive group on UEF dual-task score suggest higher association between atrophy of these brain structures and compromised dual-task performance among the MCI group.
AB - Background and Purpose: Cognitive impairment is a critical health problem in the elderly population. Research has shown that patients with mild cognitive impairment (MCI) may develop dementia in later years. Therefore, early identification of MCI could allow for interventions to help delay the progression of this devastating disease. Our objective in this study was to detect the early presence of MCI in elderly patients via neuroimaging and dual-task performance. Methods: Brain MRI scans from 21 older adult volunteers, including cognitively healthy adults (HA, n = 9, age = 68-79 years) and mild cognitively impaired (MCI, n = 12, age = 66-92 years) were analyzed using automatic segmentation techniques. Regional volume, surface area, and thickness measures were correlated with simultaneous performance of motor and cognitive tasks (dual-task) within a novel upper-extremity function (UEF) test, using multivariate analysis of variance models. Results: We found significant associations of dual-task performance with volume of five cortical brain regions (P ≤.048) and thickness of 13 regions (P ≤.043) within the frontal, temporal, and parietal lobes. There was a significant interaction effect of cognitive group on dual-task score for the inferior temporal gyrus volume (P ≤.034), and the inferior parietal lobule, inferior temporal gyrus, and middle temporal gyrus average thickness (P ≤.037). Conclusions: This study highlighted the potential of dual-tasking and MRI morphometric changes as a simple and accurate tool for early detection of cognitive impairment among community-dwelling older adults. The strong interaction effects of cognitive group on UEF dual-task score suggest higher association between atrophy of these brain structures and compromised dual-task performance among the MCI group.
KW - Automated MRI analysis
KW - dual-task
KW - mild cognitive impairment
KW - upper-extremity function
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U2 - 10.1111/jon.12845
DO - 10.1111/jon.12845
M3 - Article
C2 - 33783915
AN - SCOPUS:85103418902
VL - 31
SP - 588
EP - 601
JO - Journal of Neuroimaging
JF - Journal of Neuroimaging
SN - 1051-2284
IS - 3
ER -