Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope

Houssine Makhlouf, Andrew R. Rouse, Arthur F. Gmitro

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Optical biopsy facilitates in vivo disease diagnoses by providing a real-time in situ view of tissue in a clinical setting. Fluorescence confocal microendoscopy and optical coherence tomography (OCT) are two methods that have demonstrated significant potential in this context. These techniques provide complementary viewpoints. The high resolution and contrast associated with confocal systems allow en face visualization of sub-cellular details and cellular organization within a thin layer of biological tissue. OCT provides cross-sectional images showing the tissue microarchitecture to a depth beyond the reach of confocal systems. We present a novel design for a bench-top imaging system that incorporates both confocal and OCT modalities in the same optical train allowing the potential for rapid switching between the two imaging techniques. Preliminary results using simple phantoms show that it is possible to realize both confocal microendoscopy and OCT through a fiber bundle based imaging system.

Original languageEnglish (US)
Pages (from-to)634-644
Number of pages11
JournalBiomedical Optics Express
Issue number3
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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