Drug-Induced Vasculitis: New Insights and a Changing Lineup of Suspects

Rafael G. Grau

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


An increasing number of therapeutic agents have been associated with a vasculitic syndrome. This usually involves small vessels, primarily capillaries, venules, and arterioles in leukocytoclastic vasculitis, small-vessel disease similar to an antineutrophil cytoplasmic antibody-related vasculitis, or mid-sized muscular arteries in a polyarteritis-like picture. Antineutrophil cytoplasmic antibodies are present in many cases of vasculitis regardless of the size of the vessel involved. Monoclonal antibodies used to treat many autoimmune disorders have become the most common agents associated with drug-induced vasculitis. Important advances in epigenetics, genetics, and neutrophil apoptosis are providing new insights into the pathogenesis of both drug-induced vasculitis and idiopathic vasculitis. Although management has not changed significantly in the past few years where withdrawal of the offending agent is the primary intervention, increasing awareness of drug-induced vasculitis can lead to earlier diagnosis and prevention of severe organ damage and fatalities.

Original languageEnglish (US)
Article number71
JournalCurrent rheumatology reports
Issue number12
StatePublished - Dec 1 2015


  • Antineutrophil cytoplasmic antibodies
  • Cocaine
  • Drug-induced vasculitis
  • Hydralazine
  • Leukotrienes antagonists
  • Levamisole
  • Minocycline
  • Monoclonal antibodies
  • Propylthiouracil
  • Rituximab
  • Statins
  • Tumor necrosis factor-alpha
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology


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