@inproceedings{233580bb3f9740339d8cd0979f31e6e3,
title = "Drug delivery with light-activated gold-coated liposomes",
abstract = "With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The liposome's lipid membrane allows for encapsulation of a small volume of soluble therapeutic or diagnostic compounds, while the surrounding plasmon resonant gold structure elicits rapid release of the liposomes' contents when illuminated by laser light at wavelengths corresponding to the spectral position of the plasmon resonance band. By depositing discrete gold nanoclusters onto the surface of 100 nm diameter thermosensitive liposomes, we harness the plasmon resonance of a gold pseudo-shell while maintaining degradability to a size compatible with renal clearance. In this work we describe optimization of the liposome design which combines stable encapsulation at physiological temperatures and gold coating responsive at near infrared wavelengths. The described biocompatible composite delivery vehicle enables encapsulation and selective release of therapeutic or contrast agents upon application of a light stimulus for applications in biomedical imaging, diagnostics, therapeutics and targeted drug delivery.",
keywords = "5-FU, Drug delivery, Liposomes, Plasmon resonance",
author = "Orsinger, {G. V.} and Leung, {S. J.} and Knights-Mitchell, {S. S.} and Williams, {J. D.} and M. Romanowski",
year = "2012",
language = "English (US)",
isbn = "9781466562769",
series = "Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012",
pages = "134--137",
booktitle = "Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012",
note = "Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 ; Conference date: 18-06-2012 Through 21-06-2012",
}