Down's syndrome: A genetic disorder in biobehavioral perspective

L. Nadel

Research output: Contribution to journalReview articlepeer-review

216 Scopus citations


Down's syndrome is a genetic disorder that can lead to mental retardation of varying degrees. How this chromosomal abnormality causes mental retardation remains an open question. This paper reviews what is currently known about the neural and cognitive features of Down's syndrome, noting the growing evidence of disproportionate impairment of specific systems such as the hippocampal formation, the prefrontal cortex and the cerebellum. The development of animal models of these defects offers a way of ultimately connecting the genetic disorder to its cognitive consequences.

Original languageEnglish (US)
Pages (from-to)156-166
Number of pages11
JournalGenes, Brain and Behavior
Issue number3
StatePublished - Jun 2003


  • Down's syndrome
  • Hippocampus
  • Mental retardation

ASJC Scopus subject areas

  • Genetics
  • Neurology
  • Behavioral Neuroscience


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