Donors of HNO

Katrina M. Miranda; Herbert T. Nagasawa; John P. Toscano

doi:10.2174/1568026054679290

Donors of HNO

Katrina M. Miranda, Herbert T. Nagasawa, John P. Toscano

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.

Original language	English (US)
Pages (from-to)	649-664
Number of pages	16
Journal	Current topics in medicinal chemistry
Volume	5
Issue number	7
DOIs	https://doi.org/10.2174/1568026054679290
State	Published - 2005

Keywords

Acyl nitroso compounds
Angeli's salt
Characterization
Cyanamide
Detection
Hydroxylamines
Nitric oxide
Nitroxyl
Piloty's acid
Prodrugs
Sulfohydroxamic acids

ASJC Scopus subject areas

Drug Discovery

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title = "Donors of HNO",

abstract = "Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.",

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journal = "Current topics in medicinal chemistry",

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AU - Miranda, Katrina M.

AU - Nagasawa, Herbert T.

AU - Toscano, John P.

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AB - Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.

KW - Acyl nitroso compounds

KW - Angeli's salt

KW - Characterization

KW - Cyanamide

KW - Detection

KW - Hydroxylamines

KW - Nitric oxide

KW - Nitroxyl

KW - Piloty's acid

KW - Prodrugs

KW - Sulfohydroxamic acids

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Donors of HNO

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Keywords

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