Does rheumatoid factor always mean arthritis?

J. R. Lisse

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Rheumatoid arthritis is a clinical syndrome, and the diagnosis requires the presence of pain, swelling, and tenderness in the joints. In the absence of these features, identification of rheumatoid factor in the serum is of little use. Because rheumatoid factor is an immune complex, it is a marker of immune activation and, therefore, may be present in the circulation of persons with a variety of inflammatory conditions that stimulate the immune system. Also, 5% of the healthy population have significant titers of rheumatoid factor in their serum.

Original languageEnglish (US)
Pages (from-to)133-134+139
JournalPostgraduate medicine
Issue number6
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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