Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Kaitlin Graham; Paula F. Moon-Massat; Evan C. Unger

doi:10.1097/SHK.0000000000001060

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Kaitlin Graham
, Paula F. Moon-Massat
, Evan C. Unger

Cancer Center

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.

Original language	English (US)
Pages (from-to)	50-54
Number of pages	5
Journal	Shock
Volume	52
Issue number	1S
DOIs	https://doi.org/10.1097/SHK.0000000000001060
State	Published - Oct 1 2019

Keywords

Hypoxia
nanoemulsion
oxygen therapeutic
perfluorocarbon
prehospital resuscitation

ASJC Scopus subject areas

Emergency Medicine
Critical Care and Intensive Care Medicine

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10.1097/SHK.0000000000001060

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title = "Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review",

abstract = "Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.",

keywords = "Hypoxia, nanoemulsion, oxygen therapeutic, perfluorocarbon, prehospital resuscitation",

author = "Kaitlin Graham and Moon-Massat, \{Paula F.\} and Unger, \{Evan C.\}",

note = "Funding Information: Research support has been received from the Naval Medical Research Center (NMRC), specifically the Defense Health Program work unit, in support of Dr. Paula Moon-Massat, some of which is referred to in the manuscript: Grant \# 602115HP.3720.001.A1011 and \#603115HP.3730.001.A1247. Publisher Copyright: {\textcopyright} 2019 by the Shock Society.",

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doi = "10.1097/SHK.0000000000001060",

language = "English (US)",

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T2 - A review

AU - Graham, Kaitlin

AU - Moon-Massat, Paula F.

AU - Unger, Evan C.

N1 - Funding Information: Research support has been received from the Naval Medical Research Center (NMRC), specifically the Defense Health Program work unit, in support of Dr. Paula Moon-Massat, some of which is referred to in the manuscript: Grant # 602115HP.3720.001.A1011 and #603115HP.3730.001.A1247. Publisher Copyright: © 2019 by the Shock Society.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.

AB - Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.

KW - Hypoxia

KW - nanoemulsion

KW - oxygen therapeutic

KW - perfluorocarbon

KW - prehospital resuscitation

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DO - 10.1097/SHK.0000000000001060

M3 - Review article

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AN - SCOPUS:85072100948

SN - 1073-2322

VL - 52

SP - 50

EP - 54

JO - Shock

JF - Shock

IS - 1S

ER -

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: A review

Abstract

Keywords

ASJC Scopus subject areas

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