Abstract
Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, whereas anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This minireview summarizes our progress in developing a battlefield-ready product to prevent combat death due to hemorrhagic shock and/or TBI. Preclinical studies, for both indications, show promising effects of DDFPe as a resuscitation fluid. DDFPe may become a part of the toolkit for tactical healthcare professionals in battlefield and domestic emergency medicine.
Original language | English (US) |
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Pages (from-to) | 50-54 |
Number of pages | 5 |
Journal | Shock |
Volume | 52 |
Issue number | 1S |
DOIs | |
State | Published - Oct 1 2019 |
Keywords
- Hypoxia
- nanoemulsion
- oxygen therapeutic
- perfluorocarbon
- prehospital resuscitation
ASJC Scopus subject areas
- Emergency Medicine
- Critical Care and Intensive Care Medicine