TY - JOUR
T1 - Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?
AU - Jergović, Mladen
AU - Uhrlaub, Jennifer L.
AU - Contreras, Nico A.
AU - Nikolich-Žugich, Janko
N1 - Funding Information:
Funding This study is supported by the USPS award AG048021 from the NIH/NIA to JNZ.
Publisher Copyright:
© 2019, American Aging Association.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - In both mice and humans, the CD8 T cell compartment is expanded with age in the presence of a cytomegalovirus (CMV) infection due to an absolute increase in the CD8+ T cell effector memory (TEM) cells. It has been hypothesized that in CMV+ subjects, such accumulated TEM cells could interfere with responses to new infection by competing for space/resources or could inhibit new responses by other, undefined, means. Here we present evidence against this hypothesis. We show that MCMV-specific CD8 T cells accumulate in blood and bone marrow, but not lymph nodes (frequent sites of immune response initiation), in either persistent lifelong CMV infection or following reactivation. Moreover, adoptive transfer of effector memory T cells from MCMV positive mice into naïve animals did not interfere with either humoral or cellular response to West Nile virus or Listeria monocytogenes infection in recipient mice. We conclude that MCMV infection is unlikely to inhibit new immune responses in old animals through direct interference of MCMV-specific CD8 T cells with the priming.
AB - In both mice and humans, the CD8 T cell compartment is expanded with age in the presence of a cytomegalovirus (CMV) infection due to an absolute increase in the CD8+ T cell effector memory (TEM) cells. It has been hypothesized that in CMV+ subjects, such accumulated TEM cells could interfere with responses to new infection by competing for space/resources or could inhibit new responses by other, undefined, means. Here we present evidence against this hypothesis. We show that MCMV-specific CD8 T cells accumulate in blood and bone marrow, but not lymph nodes (frequent sites of immune response initiation), in either persistent lifelong CMV infection or following reactivation. Moreover, adoptive transfer of effector memory T cells from MCMV positive mice into naïve animals did not interfere with either humoral or cellular response to West Nile virus or Listeria monocytogenes infection in recipient mice. We conclude that MCMV infection is unlikely to inhibit new immune responses in old animals through direct interference of MCMV-specific CD8 T cells with the priming.
KW - Cytomegalovirus-specific memory T cells
KW - Lymphoid tissues
KW - West Nile virus
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U2 - 10.1007/s11357-019-00068-0
DO - 10.1007/s11357-019-00068-0
M3 - Article
C2 - 31069636
AN - SCOPUS:85066411618
VL - 41
SP - 155
EP - 163
JO - GeroScience
JF - GeroScience
SN - 2509-2715
IS - 2
ER -