DNA polymerase κ: Friend or foe?

Joann B. Sweasy

doi:10.1126/scisignal.abb2934

DNA polymerase κ: Friend or foe?

Joann B. Sweasy

Cancer Center

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

Original language	English (US)
Article number	eabb2934
Journal	Science signaling
Volume	13
Issue number	629
DOIs	https://doi.org/10.1126/scisignal.abb2934
State	Published - Apr 28 2020

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.abb2934

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title = "DNA polymerase κ: Friend or foe?",

abstract = "In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.",

author = "Sweasy, {Joann B.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works",

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AB - In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

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DNA polymerase κ: Friend or foe?

Abstract

ASJC Scopus subject areas

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