DNA polymerase κ: Friend or foe?

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In this issue of Science Signaling, Temprine et al. report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway–targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress.

Original languageEnglish (US)
Article numbereabb2934
JournalScience signaling
Issue number629
StatePublished - Apr 28 2020

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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