DNA G-quadruplex and its potential as anticancer drug target

Buket Onel; Clement Lin; Danzhou Yang

doi:10.1007/s11426-014-5235-3

DNA G-quadruplex and its potential as anticancer drug target

Buket Onel, Clement Lin, Danzhou Yang

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5′ and 3′-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small-molecule drugs.

Original language	English (US)
Pages (from-to)	1605-1614
Number of pages	10
Journal	Science China Chemistry
Volume	57
Issue number	12
DOIs	https://doi.org/10.1007/s11426-014-5235-3
State	Published - Dec 2014

Keywords

DNA G-quadruplexes
G-quadruplex-targeted small molecules
anticancer drug target
human telomeres
oncogene promoters

ASJC Scopus subject areas

General Chemistry

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10.1007/s11426-014-5235-3

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AU - Lin, Clement

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DNA G-quadruplex and its potential as anticancer drug target

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