DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Jessica J. King; Kelly L. Irving; Cameron W. Evans; Rupesh V. Chikhale; Rouven Becker; Christopher J. Morris; Cristian D. Peña Martinez; Peter Schofield; Daniel Christ; Laurence H. Hurley; Zoë A.E. Waller; K. Swaminathan Iyer; Nicole M. Smith

doi:10.1021/jacs.0c11708

DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Jessica J. King, Kelly L. Irving, Cameron W. Evans, Rupesh V. Chikhale, Rouven Becker, Christopher J. Morris, Cristian D. Peña Martinez, Peter Schofield, Daniel Christ, Laurence H. Hurley, Zoë A.E. Waller, K. Swaminathan Iyer, Nicole M. Smith

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

Original language	English (US)
Pages (from-to)	20600-20604
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	142
Issue number	49
DOIs	https://doi.org/10.1021/jacs.0c11708
State	Published - Dec 9 2020

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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King, J. J., Irving, K. L., Evans, C. W., Chikhale, R. V., Becker, R., Morris, C. J., Peña Martinez, C. D., Schofield, P., Christ, D., Hurley, L. H., Waller, Z. A. E., Iyer, K. S., & Smith, N. M. (2020). DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells. Journal of the American Chemical Society, 142(49), 20600-20604. https://doi.org/10.1021/jacs.0c11708

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title = "DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells",

abstract = "Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.",

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AU - King, Jessica J.

AU - Irving, Kelly L.

AU - Evans, Cameron W.

AU - Chikhale, Rupesh V.

AU - Becker, Rouven

AU - Morris, Christopher J.

AU - Peña Martinez, Cristian D.

AU - Schofield, Peter

AU - Christ, Daniel

AU - Hurley, Laurence H.

AU - Waller, Zoë A.E.

AU - Iyer, K. Swaminathan

AU - Smith, Nicole M.

PY - 2020/12/9

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AB - Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

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DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Abstract

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