DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?

Eric Weterings; David J. Chen

doi:10.1083/jcb.200705106

DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?

Eric Weterings, David J. Chen

Radiation Oncology

Research output: Contribution to journal › Short survey › peer-review

89 Scopus citations

Abstract

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

Original language	English (US)
Pages (from-to)	183-186
Number of pages	4
Journal	Journal of Cell Biology
Volume	179
Issue number	2
DOIs	https://doi.org/10.1083/jcb.200705106
State	Published - Oct 22 2007

ASJC Scopus subject areas

Cell Biology

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10.1083/jcb.200705106

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title = "DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?",

abstract = "The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.",

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N2 - The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

AB - The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

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DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?

Abstract

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