| Original language | English (US) |
|---|---|
| Pages (from-to) | 457-505 |
| Number of pages | 49 |
| Journal | Studies in Natural Products Chemistry |
| Volume | 20 |
| Issue number | PART F |
| DOIs | |
| State | Published - 1997 |
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
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In: Studies in Natural Products Chemistry, Vol. 20, No. PART F, 1997, p. 457-505.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - DNA-damaging natural products with potential anticancer activity
AU - Gunatilaka, A. A.Lesile
AU - Kingston, David G.I.
N1 - Funding Information: The work described in this review depended first of all on an effective collaboration as part of a National Cooperative Drug Discovery Group (NCDDG) grant (1 U01 CA 50771) awarded to the University of Virginia (Prof. S.M. Hecht, Principal Investigator), and we are particularly grateful to the National Cancer Institute for this financial support. We are also grateful to Prof. Hecht for his leadership, advice and encouragement and the provision of bioactive extracts, and to Dr. Randall K Johnson (SmithKline Beecham Pharmaceuticals) for the provision of active extracts and of the yeast strains described in this review. The work carried out at Virginia Polytechnic Institute and State University was made possible thanks to the skillful efforts of our following coworkers: Dr. A Ahmad, Ms. N. J. Baj, Profa. V. da S. Bolzani, Ms. Claudia Brochini, Dr. Q.-M. Che, Prof. E. Dagne, Mr. T. E. Glass, Prof. M. Govindan, Ms. G. Govidan, Dr. Habib-ur-Rahman, Mr. K. Harich, Dr. G. G. Harrigan, Dr. C. E. Heltzel, Dr. Y C. Kim, Mr. W. Lennox, Prof. J.-Y. Liang, Dr. W. R. Phillips, Dr. G. Samaranayake, Prof. E. Silveira, Profa. L. M. M. Valente, and Mr. C. WU. We gratefully acknowledge their valuable contribution to this program. We also gratefully acknowledge the collaboration of Dr. G.W Chan, Dr. D.S. Eggleston, Mr. L. Faucette, Dr. K Haltiwanger, and Mr. G.A Hofmann from SmithKline Beecham Pharmaceuticals, and Prof. L.M.V. Tillekeratne and Dr. E. M. K. Wijeratne from Sri Lanka. We are grateful to Profs. H. Achenbach (Germany), A Cave (France) and A Banerji (India) for samples of 4,5-dioxoaporphlnes for SAR studies. Funding Information: This review is concerned with our search for naturally occurring DNA damaging agents with potential anticancer activity as a part of a National Cooperative Drug Discovery Group funded by the U.S. National Cancer Institute and conducted in collaboration with the University of Virginia and SmithKline Beecham Pharmaceuticals. Many international collaborators from Brazil, Ethiopia, Guam, the Philippines, and Sri Lanka participated in this program directly or indirectly by providing extracts for bioassay and by working on the bioactive extracts.
PY - 1997
Y1 - 1997
UR - http://www.scopus.com/inward/record.url?scp=77957138716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957138716&partnerID=8YFLogxK
U2 - 10.1016/S1572-5995(97)80036-1
DO - 10.1016/S1572-5995(97)80036-1
M3 - Article
AN - SCOPUS:77957138716
SN - 1572-5995
VL - 20
SP - 457
EP - 505
JO - Studies in Natural Products Chemistry
JF - Studies in Natural Products Chemistry
IS - PART F
ER -