DNA as a target for drug action

Laurence H. Hurley; F. Leslie Boyd

doi:10.1016/0165-6147(88)90067-3

DNA as a target for drug action

Laurence H. Hurley, F. Leslie Boyd

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

DNA is the presumed target for a number of clinically useful anticancer drugs. In this review, Laurence Hurley and Leslie Boyd discuss the appropriateness of the term 'receptor' for DNA and outline the forseeable problems in designing drugs that will produce a defined pharmacological response through interaction with DNA. They describe the structural features which present DNA as an attractive target for drug design, and the possible characteristics of drugs that react with DNA to produce a predetermined biochemical response. Finally, they outline modern approaches to elucidating the structural and biological consequences of drug modification.

Original language	English (US)
Pages (from-to)	402-407
Number of pages	6
Journal	Trends in Pharmacological Sciences
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/0165-6147(88)90067-3
State	Published - Nov 1988
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/0165-6147(88)90067-3

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title = "DNA as a target for drug action",

abstract = "DNA is the presumed target for a number of clinically useful anticancer drugs. In this review, Laurence Hurley and Leslie Boyd discuss the appropriateness of the term 'receptor' for DNA and outline the forseeable problems in designing drugs that will produce a defined pharmacological response through interaction with DNA. They describe the structural features which present DNA as an attractive target for drug design, and the possible characteristics of drugs that react with DNA to produce a predetermined biochemical response. Finally, they outline modern approaches to elucidating the structural and biological consequences of drug modification.",

author = "Hurley, {Laurence H.} and Boyd, {F. Leslie}",

note = "Funding Information: Acknowledgements This work was supported by the National Institutes of Health grants PO1 HL22619 (AS), T32 HL07382 (AS) and RO1 HL41088 (PLV). The artwork by MS Gwen Kraft is greatly appreciated.",

year = "1988",

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doi = "10.1016/0165-6147(88)90067-3",

language = "English (US)",

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T1 - DNA as a target for drug action

AU - Hurley, Laurence H.

AU - Boyd, F. Leslie

N1 - Funding Information: Acknowledgements This work was supported by the National Institutes of Health grants PO1 HL22619 (AS), T32 HL07382 (AS) and RO1 HL41088 (PLV). The artwork by MS Gwen Kraft is greatly appreciated.

PY - 1988/11

Y1 - 1988/11

N2 - DNA is the presumed target for a number of clinically useful anticancer drugs. In this review, Laurence Hurley and Leslie Boyd discuss the appropriateness of the term 'receptor' for DNA and outline the forseeable problems in designing drugs that will produce a defined pharmacological response through interaction with DNA. They describe the structural features which present DNA as an attractive target for drug design, and the possible characteristics of drugs that react with DNA to produce a predetermined biochemical response. Finally, they outline modern approaches to elucidating the structural and biological consequences of drug modification.

AB - DNA is the presumed target for a number of clinically useful anticancer drugs. In this review, Laurence Hurley and Leslie Boyd discuss the appropriateness of the term 'receptor' for DNA and outline the forseeable problems in designing drugs that will produce a defined pharmacological response through interaction with DNA. They describe the structural features which present DNA as an attractive target for drug design, and the possible characteristics of drugs that react with DNA to produce a predetermined biochemical response. Finally, they outline modern approaches to elucidating the structural and biological consequences of drug modification.

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U2 - 10.1016/0165-6147(88)90067-3

DO - 10.1016/0165-6147(88)90067-3

M3 - Review article

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AN - SCOPUS:0023686169

SN - 0165-6147

VL - 9

SP - 402

EP - 407

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 11

ER -

DNA as a target for drug action

Abstract

ASJC Scopus subject areas

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