DNA and its associated processes as targets for cancer therapy

Laurence H. Hurley

doi:10.1038/nrc749

DNA and its associated processes as targets for cancer therapy

Laurence H. Hurley

Pharmacology and Toxicology

Research output: Contribution to journal › Review article › peer-review

1254 Scopus citations

Abstract

DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

Original language	English (US)
Pages (from-to)	188-200
Number of pages	13
Journal	Nature Reviews Cancer
Volume	2
Issue number	3
DOIs	https://doi.org/10.1038/nrc749
State	Published - Mar 2002

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc749

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title = "DNA and its associated processes as targets for cancer therapy",

abstract = "DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?",

author = "Hurley, {Laurence H.}",

note = "Funding Information: I thank D. M. Bishop for preparing, proofreading and editing the text and for helping to create the figures. L. H. H. is supported by grants from the National Cancer Institute, the National Foundation for Cancer Research and the Arizona Disease Control Research Commission.",

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N2 - DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

AB - DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

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DNA and its associated processes as targets for cancer therapy

Abstract

ASJC Scopus subject areas

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