DNA and its associated processes as targets for cancer therapy

Research output: Contribution to journalReview articlepeer-review

1163 Scopus citations


DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

Original languageEnglish (US)
Pages (from-to)188-200
Number of pages13
JournalNature Reviews Cancer
Issue number3
StatePublished - Mar 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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