@article{3af961d171c64a8ea8b597e61c59cdd9,
title = "Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via the Groebke-Blackburn-Bienaym{\'e} and TBAB-Mediated Cascade Reaction in One Pot",
abstract = "A facile and metal-free one-pot protocol for the synthesis of fused imidazopyridine scaffolds has been developed. This novel protocol combines the Groebke-Blackburn-Bienaym{\'e} reaction (GBBR) with a sequential TBAB-mediated cyclization cascade. Biological evaluation demonstrated that compound 6a inhibits human prostate cancer cell DU-145 proliferation with an IC50 of 1.6 μM. The molecular mechanism study indicates that 6a significantly suppresses the oncogenic Erk kinase phosphorylation at 3 μM.",
author = "Yong Li and Huang, {Jiu Hong} and Wang, {Juan Li} and Song, {Gui Ting} and Tang, {Dian Yong} and Fang Yao and Lin, {Hui Kuan} and Wei Yan and Li, {Hong Yu} and Xu, {Zhi Gang} and Chen, {Zhong Zhu}",
note = "Funding Information: The authors would like to thank the Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcyjA1328, cstc2015zdcy-ztzx0191, and cstc2015zdcy-ztzx120003) and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (R2013XY01, R2013XY02, Z2016BX02, and 2017RBX09). We would also like to thank Ms. H. Z. Liu and J. Xu for obtaining the LC–MS, HRMS, and NMR data. The graphic art was designed by Assistant Professor Xiaoyong Gao of the Chongqing University of Arts and Sciences. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = oct,
day = "4",
doi = "10.1021/acs.joc.9b01385",
language = "English (US)",
volume = "84",
pages = "12632--12638",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "19",
}