Abstract
A transition-metal free, high yielding and efficient three-component reaction was designed and incorporated into two sequential oxidation and cyclization reaction cascades in one-pot with the assistance of microwave irradiation. A chemical collection of functionalized 3-substituted imidazopyridines was prepared by means of the mild reaction and simple operational procedure. The reaction has a broad tolerance for a variety of substituted carbonyl aldehydes, anilines and 2-phenyl-imidazo[1,2-a]pyridines. Screening in several cancer cell lines was conducted. Compound 9 i exhibited good potency against HeLa cell lines and this work validated the feasibility of the methodology for generating bioactive compounds. (Figure presented.).
Original language | English (US) |
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Pages (from-to) | 3655-3661 |
Number of pages | 7 |
Journal | Advanced Synthesis and Catalysis |
Volume | 360 |
Issue number | 19 |
DOIs | |
State | Published - Oct 4 2018 |
Keywords
- Anti-cancer
- Imidazopyridines
- One-pot
- multicomponent reactions (MCRs)
- three-component reaction
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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CCDC 1815595: Experimental Crystal Structure Determination
Song, G. (Creator), McConnell, N. (Creator), Chen, Z. (Creator), Yao, X. (Creator), Huang, J. (Creator), Lei, J. (Creator), Lin, H. (Creator), Frett, B. (Creator), Li, H. (Creator) & Xu, Z. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1yy8lr, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1yy8lr&sid=DataCite
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