@article{3fdf4f5d1e1e4ecdba2a10227827f460,
title = "Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction",
abstract = "A transition-metal free, high yielding and efficient three-component reaction was designed and incorporated into two sequential oxidation and cyclization reaction cascades in one-pot with the assistance of microwave irradiation. A chemical collection of functionalized 3-substituted imidazopyridines was prepared by means of the mild reaction and simple operational procedure. The reaction has a broad tolerance for a variety of substituted carbonyl aldehydes, anilines and 2-phenyl-imidazo[1,2-a]pyridines. Screening in several cancer cell lines was conducted. Compound 9 i exhibited good potency against HeLa cell lines and this work validated the feasibility of the methodology for generating bioactive compounds. (Figure presented.).",
keywords = "Anti-cancer, Imidazopyridines, One-pot, multicomponent reactions (MCRs), three-component reaction",
author = "Song, {Gui Ting} and Nicholas McConnell and Chen, {Zhong Zhu} and Yao, {Xiao Fang} and Huang, {Jiu Hong} and Jie Lei and Lin, {Hui Kuan} and Brendan Frett and Li, {Hong yu} and Xu, {Zhi Gang}",
note = "Funding Information: The authors would like to thank Chongqing Science and Technology Committee Project of China under grant No. cstc2016jcyjA0534 and cstc2015zdcy-ztzx120003; The grants from Chongqing Education commission Project of China under Grant No. KJZH17129, KJ1501130, KJ1711284 and KJ1711287; Chongqing University of Arts and Science R2015BX03. HL and BF were supported by the grants (NIH 1R01CA194094-010 and 1R01CA197178-01A1). HKL was supported by the grants (NIH R01 CA182424 and R01CA193813). This work was also supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences from the National Institutes of Health under grant number “P20 GM109005”. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = oct,
day = "4",
doi = "10.1002/adsc.201800728",
language = "English (US)",
volume = "360",
pages = "3655--3661",
journal = "Advanced Synthesis and Catalysis",
issn = "1615-4150",
publisher = "Wiley-VCH Verlag",
number = "19",
}