A transition-metal free, high yielding and efficient three-component reaction was designed and incorporated into two sequential oxidation and cyclization reaction cascades in one-pot with the assistance of microwave irradiation. A chemical collection of functionalized 3-substituted imidazopyridines was prepared by means of the mild reaction and simple operational procedure. The reaction has a broad tolerance for a variety of substituted carbonyl aldehydes, anilines and 2-phenyl-imidazo[1,2-a]pyridines. Screening in several cancer cell lines was conducted. Compound 9 i exhibited good potency against HeLa cell lines and this work validated the feasibility of the methodology for generating bioactive compounds. (Figure presented.).
- multicomponent reactions (MCRs)
- three-component reaction
ASJC Scopus subject areas
- Organic Chemistry
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Song, G. (Creator), McConnell, N. (Creator), Chen, Z. (Creator), Yao, X. (Creator), Huang, J. (Creator), Lei, J. (Creator), Lin, H. (Creator), Frett, B. (Creator), Li, H. (Creator) & Xu, Z. (Creator), Cambridge Crystallographic Data Centre, 2018