Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)2-Catalyzed Annulation of N-Allylamidines

Li Xu; Hongxian Li; Ziyang Liao; Kaiyan Lou; Hexin Xie; Hao Li; Wei Wang

doi:10.1021/acs.orglett.5b01435

Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)₂-Catalyzed Annulation of N-Allylamidines

Li Xu, Hongxian Li, Ziyang Liao, Kaiyan Lou, Hexin Xie, Hao Li, Wei Wang

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

A Pd(OAc)₂-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O₂ from air and/or a ligand and Pd(OAc)₂, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.

Original language	English (US)
Pages (from-to)	3434-3437
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	14
DOIs	https://doi.org/10.1021/acs.orglett.5b01435
State	Published - Jul 17 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A Pd(OAc)2-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O2 from air and/or a ligand and Pd(OAc)2, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.",

author = "Li Xu and Hongxian Li and Ziyang Liao and Kaiyan Lou and Hexin Xie and Hao Li and Wei Wang",

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T1 - Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)2-Catalyzed Annulation of N-Allylamidines

AU - Xu, Li

AU - Li, Hongxian

AU - Liao, Ziyang

AU - Lou, Kaiyan

AU - Xie, Hexin

AU - Li, Hao

AU - Wang, Wei

PY - 2015/7/17

Y1 - 2015/7/17

N2 - A Pd(OAc)2-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O2 from air and/or a ligand and Pd(OAc)2, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.

AB - A Pd(OAc)2-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O2 from air and/or a ligand and Pd(OAc)2, imidazoles were obtained. Nonetheless, under microwave (MW) irradiation in a sealed system, quinazolines as major products were produced.

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Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)₂-Catalyzed Annulation of N-Allylamidines

Abstract

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