Abstract
A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7846-7849 |
| Number of pages | 4 |
| Journal | Dalton Transactions |
| Volume | 42 |
| Issue number | 22 |
| DOIs | |
| State | Published - May 14 2013 |
ASJC Scopus subject areas
- General Chemistry
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CCDC 915454: Experimental Crystal Structure Determination
Chang, T. M. (Creator) & Tomat, E. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cczqls1, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczqls1&sid=DataCite
Dataset
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CCDC 915453: Experimental Crystal Structure Determination
Chang, T. M. (Creator) & Tomat, E. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cczqlr0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczqlr0&sid=DataCite
Dataset
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