Abstract
A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.
Original language | English (US) |
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Pages (from-to) | 7846-7849 |
Number of pages | 4 |
Journal | Dalton Transactions |
Volume | 42 |
Issue number | 22 |
DOIs | |
State | Published - Jun 14 2013 |
ASJC Scopus subject areas
- Inorganic Chemistry
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CCDC 915453: Experimental Crystal Structure Determination
Chang, T. M. (Creator) & Tomat, E. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cczqlr0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczqlr0&sid=DataCite
Dataset
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CCDC 915454: Experimental Crystal Structure Determination
Chang, T. M. (Creator) & Tomat, E. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cczqls1, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cczqls1&sid=DataCite
Dataset