Abstract
Activation of endogenous opioid systems by electroconvulsive shock (ECS) produced naloxone-reversible thermal analgesia (52 °C hot plate) 5 min after ECS administration. Although pioid peptides injected intracerebroventricularly have previously been found to inhibit gastrointestinal motility, ECS treatment did not affect gastric emptying, small or large intestinal transit. These results suggest that centrally-mediated opioid analgesia and changes in gastrointestinal motility are initiated through independent mechanisms.
Original language | English (US) |
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Pages (from-to) | 354-357 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 271 |
Issue number | 2 |
DOIs | |
State | Published - Jul 25 1983 |
Keywords
- electroconvulsive shock
- endogenous opioids
- gastrointestinal motility
- thermal analgesia
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology