Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy

Kevin J. Frankowski, Michael P. Hedrick, Palak Gosalia, Kelin Li, Shenghua Shi, David Whipple, Partha Ghosh, Thomas E. Prisinzano, Frank J. Schoenen, Ying Su, S. Vasile, Eduard Sergienko, Wilson Gray, Santosh Hariharan, Loribelle Milan, Susanne Heynen-Genel, Arianna Mangravita-Novo, Michael Vicchiarelli, Layton H. Smith, John M. StreicherMarc G. Caron, Lawrence S. Barak, Laura M. Bohn, Thomas D.Y. Chung, Jeffrey Aubé

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Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science

Neuroscience

Chemistry