Discovery of novel bis-evodiamine derivatives with potent antitumor activity

Huixin Liang, Wei Wang, Fugui Zhu, Shuqiang Chen, Dan Liu, Chunquan Sheng

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Inspired by antitumor natural product evodiamine, a series of novel bis-evodiamine derivatives were designed and synthesized, which showed potent antitumor activity. In particular, compound 13b effectively inhibited the proliferation and migration of HCT116 cells. Further mechanism studies revealed that compound 13b acted by inducing HCT116 cell apoptosis and arresting the cell cycle at the G2/M phase. Thus, compound 13b represents a promising lead compound for the discovery of novel antitumor agents.

Original languageEnglish (US)
Article number116793
JournalBioorganic and Medicinal Chemistry
Volume65
DOIs
StatePublished - Jul 1 2022
Externally publishedYes

Keywords

  • Antitumor activity
  • Apoptosis
  • Bis-evodiamine
  • Twin drug

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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