Discovery of cis - N -(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene- 2-carboximidamide: A 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities

Subhash C. Annedi, Jailall Ramnauth, Shawn P. Maddaford, Paul Renton, Suman Rakhit, Gabriela Mladenova, Peter Dove, Sarah Silverman, John S. Andrews, Milena D. Felice, Frank Porreca

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Pharmacology, Toxicology and Pharmaceutical Science