Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins

Karson J. Kump, Lei Miao, Ahmed S.A. Mady, Nurul H. Ansari, Uttar K. Shrestha, Yuting Yang, Mohan Pal, Chenzhong Liao, Andrej Perdih, Fardokht A. Abulwerdi, Krishnapriya Chinnaswamy, Jennifer L. Meagher, Jacob M. Carlson, May Khanna, Jeanne A. Stuckey, Zaneta Nikolovska-Coleska

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

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  • The crystal structure of anti-apoptotic Mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21

    Kump, K. J. (Contributor), Miao, L. (Contributor), Mady, A. S. A. (Contributor), Ansari, N. H. (Contributor), Shrestha, U. K. (Contributor), Yang, Y. (Contributor), Pal, M. (Contributor), Liao, C. (Contributor), Perdih, A. (Contributor), Abulwerdi, F. A. (Contributor), Chinnaswamy, K. (Contributor), Meagher, J. L. (Contributor), Carlson, J. M. (Contributor), Khanna, M. (Contributor), Stuckey, J. A. (Contributor) & Nikolovska-Coleska, Z. (Contributor), Protein Data Bank (PDB), Mar 4 2020

    DOI: 10.2210/pdb6U6F/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u6f

    Dataset

  • Mcl-1 bound to compound 17

    Kump, K. J. (Contributor), Miao, L. (Contributor), Mady, A. S. A. (Contributor), Ansari, N. H. (Contributor), Shrestha, U. K. (Contributor), Yang, Y. (Contributor), Pal, M. (Contributor), Liao, C. (Contributor), Perdih, A. (Contributor), Abulwerdi, F. A. (Contributor), Chinnaswamy, K. (Contributor), Meagher, J. L. (Contributor), Carlson, J. M. (Contributor), Khanna, M. (Contributor), Stuckey, J. A. (Contributor) & Nikolovska-Coleska, Z. (Contributor), Protein Data Bank (PDB), Mar 4 2020

    DOI: 10.2210/pdb6U64/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u64

    Dataset

  • Mcl-1 bound to compound 24

    Kump, K. J. (Contributor), Miao, L. (Contributor), Mady, A. S. A. (Contributor), Ansari, N. H. (Contributor), Shrestha, U. K. (Contributor), Yang, Y. (Contributor), Pal, M. (Contributor), Liao, C. (Contributor), Perdih, A. (Contributor), Abulwerdi, F. A. (Contributor), Chinnaswamy, K. (Contributor), Meagher, J. L. (Contributor), Carlson, J. M. (Contributor), Khanna, M. (Contributor), Stuckey, J. A. (Contributor) & Nikolovska-Coleska, Z. (Contributor), Protein Data Bank (PDB), Mar 4 2020

    DOI: 10.2210/pdb6U67/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u67

    Dataset

  • Mcl-1 bound to compound 17

    Kump, K. J. (Contributor), Miao, L. (Contributor), Mady, A. S. A. (Contributor), Ansari, N. H. (Contributor), Shrestha, U. K. (Contributor), Yang, Y. (Contributor), Pal, M. (Contributor), Liao, C. (Contributor), Perdih, A. (Contributor), Abulwerdi, F. A. (Contributor), Chinnaswamy, K. (Contributor), Meagher, J. L. (Contributor), Carlson, J. M. (Contributor), Khanna, M. (Contributor), Stuckey, J. A. (Contributor) & Nikolovska-Coleska, Z. (Contributor), Protein Data Bank (PDB), Mar 4 2020

    DOI: 10.2210/pdb6U63/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u63

    Dataset

  • Mcl-1 bound to compound 19

    Kump, K. J. (Contributor), Miao, L. (Contributor), Mady, A. S. A. (Contributor), Ansari, N. H. (Contributor), Shrestha, U. K. (Contributor), Yang, Y. (Contributor), Pal, M. (Contributor), Liao, C. (Contributor), Perdih, A. (Contributor), Abulwerdi, F. A. (Contributor), Chinnaswamy, K. (Contributor), Meagher, J. L. (Contributor), Carlson, J. M. (Contributor), Khanna, M. (Contributor), Stuckey, J. A. (Contributor) & Nikolovska-Coleska, Z. (Contributor), Protein Data Bank (PDB), Mar 4 2020

    DOI: 10.2210/pdb6U65/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u65

    Dataset