@inproceedings{55649d2afe09493381fa3bc53eb385e8,
title = "Disassembly of myofibrils in adult cardiomyocytes during dedifferentiation",
abstract = "Using hybrid TPEF-SHG imaging and immunocytological techniques, we studied dedifferentiation of adult cardiomyocytes. First, the myofibrils shrank to shorten the sarcomere length. At the cell ends, the striated pattern of myosin filaments began to dissociate; at the center of the cell, the striated pattern of alpha-actinin first faded away and reappeared near the cell membrane during dedifferentiation. The results suggest that when freshly isolated adult cardiomyocytes are used to model cardiac muscle, the end-to-end connection may be important to maintain their striated myofibrillar structure and rod-shape morphology.",
author = "Honghai Liu and Wan Qin and Yonghong Shao and Zhonghai Wang and Huaxiao Yang and Runyan, {Raymond B.} and Borg, {Thomas K.} and Gao, {Bruce Z.}",
year = "2013",
doi = "10.1117/12.2005156",
language = "English (US)",
isbn = "9780819493569",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI",
note = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI ; Conference date: 02-02-2013 Through 05-02-2013",
}