Straight to the point: An organocatalyzed, direct preparation of 3,4-disubstituted benzaldehydes from simple enals under mild conditions without the need for an additional oxidant has been developed. Notably, self-dimerization of an enal precursor and cross-dimerization of two distinct enals have been realized with high regio- and chemoselectivity to give structurally diverse 3,4-substituted benzaldehydes in good yields (76-99 %).
|Original language||English (US)|
|Number of pages||5|
|Journal||Chemistry - A European Journal|
|State||Published - Aug 6 2012|
- cascade reactions
ASJC Scopus subject areas
- Organic Chemistry