Abstract
Straight to the point: An organocatalyzed, direct preparation of 3,4-disubstituted benzaldehydes from simple enals under mild conditions without the need for an additional oxidant has been developed. Notably, self-dimerization of an enal precursor and cross-dimerization of two distinct enals have been realized with high regio- and chemoselectivity to give structurally diverse 3,4-substituted benzaldehydes in good yields (76-99 %).
Original language | English (US) |
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Pages (from-to) | 9770-9774 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 18 |
Issue number | 32 |
DOIs | |
State | Published - Aug 6 2012 |
Externally published | Yes |
Keywords
- arenes
- aromatization
- cascade reactions
- dimerization
- organocatalysis
ASJC Scopus subject areas
- General Chemistry
- Catalysis
- Organic Chemistry