Direct transformation of simple enals to 3,4-disubstituted benzaldehydes under mild reaction conditions via an organocatalytic regio- and chemoselective dimerization cascade

Xixi Song, Xinshuai Zhang, Shilei Zhang, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Straight to the point: An organocatalyzed, direct preparation of 3,4-disubstituted benzaldehydes from simple enals under mild conditions without the need for an additional oxidant has been developed. Notably, self-dimerization of an enal precursor and cross-dimerization of two distinct enals have been realized with high regio- and chemoselectivity to give structurally diverse 3,4-substituted benzaldehydes in good yields (76-99 %).

Original languageEnglish (US)
Pages (from-to)9770-9774
Number of pages5
JournalChemistry - A European Journal
Volume18
Issue number32
DOIs
StatePublished - Aug 6 2012
Externally publishedYes

Keywords

  • arenes
  • aromatization
  • cascade reactions
  • dimerization
  • organocatalysis

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • Organic Chemistry

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