Abstract
A procedure has been developed for direct, asymmetric aldol reactions of α,α-dialkyl aldehydes with aromatic aldehydes, which produces quaternary carbon-containing β-hydroxy carbonyl compounds. The processes, promoted by the organocatalyst (S) pyrrolidine sulfonamide, take place in high yields with exceptionally high levels of enantioselectivities.
Original language | English (US) |
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Pages (from-to) | 5077-5079 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 30 |
DOIs | |
State | Published - Jul 25 2005 |
Externally published | Yes |
Keywords
- Aldehyde
- Aldol reaction
- Asymmetric catalysis
- Organocatalyst
- Pyrrolidine sulfonamide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry