Direct, pyrrolidine sulfonamide promoted enantioselective aldol reactions of α,α-dialkyl aldehydes: Synthesis of quaternary carbon-containing β-hydroxy carbonyl compounds

Wei Wang, Hao Li, Jian Wang

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

A procedure has been developed for direct, asymmetric aldol reactions of α,α-dialkyl aldehydes with aromatic aldehydes, which produces quaternary carbon-containing β-hydroxy carbonyl compounds. The processes, promoted by the organocatalyst (S) pyrrolidine sulfonamide, take place in high yields with exceptionally high levels of enantioselectivities.

Original languageEnglish (US)
Pages (from-to)5077-5079
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number30
DOIs
StatePublished - Jul 25 2005
Externally publishedYes

Keywords

  • Aldehyde
  • Aldol reaction
  • Asymmetric catalysis
  • Organocatalyst
  • Pyrrolidine sulfonamide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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