Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications

Liying Chen; Lisa S. Gobar; Negar G. Knowles; Donald W. Wilson; Harrison H. Barrett

doi:10.1109/TNS.2009.2023519

Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications

Liying Chen, Lisa S. Gobar, Negar G. Knowles, Donald W. Wilson, Harrison H. Barrett

Medical Imaging

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal ¹⁸ F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

Original language	English (US)
Article number	5280506
Pages (from-to)	2628-2635
Number of pages	8
Journal	IEEE Transactions on Nuclear Science
Volume	56
Issue number	5
DOIs	https://doi.org/10.1109/TNS.2009.2023519
State	Published - Oct 2009

Keywords

Charged particle
Dynamic imaging
In vivo
Resolution
Sensitivity

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/TNS.2009.2023519

Cite this

@article{00422eebe18c4dbc9ad4e832def00aa2,

title = "Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications",

abstract = "Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.",

keywords = "Charged particle, Dynamic imaging, In vivo, Resolution, Sensitivity",

author = "Liying Chen and Gobar, {Lisa S.} and Knowles, {Negar G.} and Wilson, {Donald W.} and Barrett, {Harrison H.}",

note = "Funding Information: Manuscript received April 21, 2008; revised October 11, 2008. Current version published October 07, 2009. This work was supported by the National Institutes of Health under Grant P41 EB002035 and by the Department of Radiology under a Departmental Internal Grant. L. Chen, L. S. Gobar, and D. W. Wilson are with the Department of Radiology, University of Arizona, Tucson, AZ 85724 USA. N. G. Knowles is with the Department of Radiology, University of Michigan, Ann Arbor, MI 48109 USA. H. H. Barrett is with the Department of Radiology, the College of Optical Sciences, and the Program of Applied Mathematics, University of Arizona, Tucson, AZ 85721 USA. Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TNS.2009.2023519",

year = "2009",

month = oct,

doi = "10.1109/TNS.2009.2023519",

language = "English (US)",

volume = "56",

pages = "2628--2635",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "5",

}

TY - JOUR

T1 - Direct charged-particle imaging system using an ultra-thin phosphor

T2 - Physical characterization and dynamic applications

AU - Chen, Liying

AU - Gobar, Lisa S.

AU - Knowles, Negar G.

AU - Wilson, Donald W.

AU - Barrett, Harrison H.

N1 - Funding Information: Manuscript received April 21, 2008; revised October 11, 2008. Current version published October 07, 2009. This work was supported by the National Institutes of Health under Grant P41 EB002035 and by the Department of Radiology under a Departmental Internal Grant. L. Chen, L. S. Gobar, and D. W. Wilson are with the Department of Radiology, University of Arizona, Tucson, AZ 85724 USA. N. G. Knowles is with the Department of Radiology, University of Michigan, Ann Arbor, MI 48109 USA. H. H. Barrett is with the Department of Radiology, the College of Optical Sciences, and the Program of Applied Mathematics, University of Arizona, Tucson, AZ 85721 USA. Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TNS.2009.2023519

PY - 2009/10

Y1 - 2009/10

N2 - Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

AB - Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

KW - Charged particle

KW - Dynamic imaging

KW - In vivo

KW - Resolution

KW - Sensitivity

UR - http://www.scopus.com/inward/record.url?scp=70350164709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350164709&partnerID=8YFLogxK

U2 - 10.1109/TNS.2009.2023519

DO - 10.1109/TNS.2009.2023519

M3 - Article

AN - SCOPUS:70350164709

SN - 0018-9499

VL - 56

SP - 2628

EP - 2635

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 5

M1 - 5280506

ER -

Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this