Abstract
Dilated cardiomyopathy (DCM) is a clinically relevant disease that can occur independently or secondary to other diseases such as HIV infection and AIDS. To study this latter process, we used a model in which mice are infected with the LP-BM5 murine AIDS (MAIDS) retrovirus. Cardiac function of control and infected mice was determined through the in vivo analysis of left ventricular pressure-volume loops. Furthermore, the role of myocarditis was investigated through immunohistochemistry for T-cell, B-cell, and macrophage cardiac infiltrates and Northern blot analysis for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). End-systolic and end-diastolic volumes were significantly increased and ventricular stiffness was significantly decreased in infected mice, consistent with DCM; however, no staining for inflammatory cellular infiltrates or TNF-α and iNOS was seen. These data support the conclusion that the LP-BM5 HIV model virus causes DCM in the absence of chronic cardiac inflammation. These findings support MAIDS retroviral infection as a new model of idiopathic DCM in which myocarditis does not occur.
Original language | English (US) |
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Pages (from-to) | 317-325 |
Number of pages | 9 |
Journal | Cardiovascular toxicology |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - 2004 |
Keywords
- Dilated cardiomyopathy
- Murine acquired immunodeficiency syndrome
- Viral myocarditis
ASJC Scopus subject areas
- Molecular Biology
- Toxicology
- Cardiology and Cardiovascular Medicine